BLOOD-BRAIN BARRIER – ITS IMPLICATION IN DRUG TRANSPORT: NOVEL STRATEGIES IN DRUG DELIVERY TO THE BRAIN

ABSTRACT The brain is a fragile organ as well as complicated. The brain is protected from many toxic substances and various chemicals by the presence of two barriers namely blood brain barrier (BBB) and blood cerebrospinal fluid barrier (BCSFB). BBB it protects the brain because of restrictive angio -architecture with endothelial cells, tight junctions and peculiar transport system. The routes of drug targeting to the brain now become an important tool in the pharmaceutical field because of many complicated diseases of the brain. There are some limitations for the trans nasal drug delivery, trans cranial drug, BBB disruption, lipidization of molecules for delivery of drugs., Therefore various novel technologies are entered like nanotechnology, liposomal drug delivery and Molecular Trojan Horses. This review includes endogenous transporters which place a role in transport of drug in to the brain, drug delivery in to the brain along with limitations and discussed the novel routes of drug delivery in to the brain
. KEYWORDS: Blood brain barrier, Drug delivery, Transporters, Nanotechnology,
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