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Wednesday, August 10, 2011

Development and characterization of orodispersible tablets of famotidine containing a subliming agent

Purpose: The purpose of the present research was to the effect of camphor as a subliming agent on the mouth dissolving property of famotidine tablets.

Method: Orodispersible tablets of famotidine were prepared using camphor as subliming agent and sodium starch glycollate together with crosscarmellose sodium as superdisintegrants. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro and in-vivo dispersion, mouth feel and in vitro dissolution.

Result: All the formulations showed low weight variation with dispersion time less than 30 seconds and rapid in vitro dissolution. The results revealed that the tablets containing subliming agent had a good dissolution profile. The drug content of all the formulations was within the acceptable limits of the United States Pharmacopoeia XXVII. The optimized formulation showed good release profile with maximum drug being released at all time intervals.

Conclusion: This work helped in understanding the effect of formulation processing variables especially the subliming agent on the drug release profile. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.

Keywords : Mouth dissolving tablet, Famotidine, Subliming agent, Super disintegrant, Camphor.

S Furtado*, R Deveswaran, S Bharath, BV Basavaraj, S Abraham and V Madhavan
Tropical Journal of Pharmaceutical Research, December 2008; 7(4): 1185-1189


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