In the early 1900s, Paul Ehrlich first defined pharmacophores as molecule frameworks that carry the essential features responsible for a drug's biological activity, and the modern definition is little changed. The 27 studies here begin by tracing the evolution of the concept in pharmaceutical research, then cover analog-based and receptor-based varieties, new algorithms, and the future of research. Among the specific topics: pharmacophores based on multiple common-feature alignments; modeling programs including HypoGen, DISCO, Catalyst, HipHop, GASP, Chem-X, Apex-3D, CoMF A; pharmacophore-based molecular docking, a technique for developing a pharmacophore model that accommodates inherent protein flexibility; and the effect of variable weights and tolerances on predictive model generation. Books in Print lists only one other book on the topic of pharmacophores.
Saturday, January 26, 2013
Important Links
Today's Visitors
Search Books and Material
Contact Us
Popular Posts
-
The science and technology associated with pharmacy has progressed enormously over the past few decades. Significant ad...
-
Hitesh B.Katariya Gujarat, India. E mail id: a dmin@pharmagupshup.in pharmagupshup@gmail.com Mobile No: +91 999...
-
pharmaceutical Journals & Magazines Academic Medicine Academic Medicine is the official, peer-reviewed journal of...
-
Date Brand Name Product Description Reason/ Problem Company Details/ Photo 10/19/2012 Banana B...
-
Lisa Henderson For the post-surgery patient in recovery, the drug addict in ER, late-stage cancer patients, and the many who suffer ...
0 comments:
Post a Comment