ABSTRACT
In present times, the pelletization technologies are gaining much attention as they represent an efficien t path way for manufacture of oral drug delivery systems. T his is due to the reaso n that pellets o ffer many therapeutic, technological as well as biopharmaceutical advantages over the conventional o ral do sage forms.
Pelletization techniqu e enables the formation o f spherical beads or pellets with a mean diameter usually rangin g from 0.5 -2.0 mm which can be eventually coated for preparation o f modified release dosage forms. Pelletization leads to an improvement in flowability, appearance and mixing properties thus avoiding
generation o f excessive dust and redu cing segregation, and , generally, eliminatin g undesirable properties and improving the physical and chemical properties o f fine po wders. Pellets are produced by various techniques, such as, extrusio n/ spheronization, layering, cryopelletization , freeze pelletization, spray congealing , spray drying and compression. Among st various techniques, Extrusion/Spheronization technique is th e most widely utilized technique due to its high efficiency and simple and fast processing. The aim of this paper is to review some general aspects about pellets and pelletization and some common techniques being utilized in the pharmaceutical indu stry.
KEYWORDS
: Pelletization, extru sion, spheronization, cryopelletization.
In present times, the pelletization technologies are gaining much attention as they represent an efficien t path way for manufacture of oral drug delivery systems. T his is due to the reaso n that pellets o ffer many therapeutic, technological as well as biopharmaceutical advantages over the conventional o ral do sage forms.
Pelletization techniqu e enables the formation o f spherical beads or pellets with a mean diameter usually rangin g from 0.5 -2.0 mm which can be eventually coated for preparation o f modified release dosage forms. Pelletization leads to an improvement in flowability, appearance and mixing properties thus avoiding
generation o f excessive dust and redu cing segregation, and , generally, eliminatin g undesirable properties and improving the physical and chemical properties o f fine po wders. Pellets are produced by various techniques, such as, extrusio n/ spheronization, layering, cryopelletization , freeze pelletization, spray congealing , spray drying and compression. Among st various techniques, Extrusion/Spheronization technique is th e most widely utilized technique due to its high efficiency and simple and fast processing. The aim of this paper is to review some general aspects about pellets and pelletization and some common techniques being utilized in the pharmaceutical indu stry.
KEYWORDS
: Pelletization, extru sion, spheronization, cryopelletization.
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