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Saturday, December 17, 2011

Pharmacology Question Paper for GPAT & NIPER JEE

Pharmacology Mcqs FOR GPAT & NIPER JEE :

1: A highly ionized drug
a. Is excreted mainly by the kidney
b. Can cross the placental barrier easily
c. Is well absorbed from the intestine
d. Accumulates in the cellular lipids

2: All of the following hormones have cell surface receptors except
a. Adrenaline
b. GH
c. Insulin
d. Thyroxine

3: Which one of the following is true of adrenal suppression due to steroid therapy?
a. It is not associated with atrophy of adrenal glands
b. It does not occur in patients receiving inhaled steroids
c. It should be expected in anyone receiving greater than 5mg of prednisolone daily
d. Following cessation, the stress response normalizes after 8 weeks

4: With which of the following theophylline has an antagonistic interaction?
a. Histamine receptors
b. Bradykinin receptors
c. Adenosine receptors
d. Imidazoline receptors

5: Which one of the following drugs increases gastrointestinal motility?
a. Glycopyrrolate
b. Atropine
c. Neostigmine
d. Fentanyl

6: Which one of the following drugs has been shown to offer protection from gastric aspiration
syndrome in a patient with symptoms of flux?

a. Ondansetron
b. Metaclopramide
c. Sodium citrate
d. Atropine

7: The following drugss have significant drug interactions with digoxin except :
a. Cholestyramine
b. Thiazide diuretics
c. Quinine
d. Amlodipine

8: One of the following is not true about nesiritide
a. It is a brain natriuretic peptide analogue
b. It is used in acutely decompensated heart failure
c. It has significant oral absorption
d. It has a short half life

9: Dry mouth during antidepressant therapy is caused by blockade of
a. Muscarinic acetylcholine receptors
b. Serotonergic receptors
c. Dopaminergic receptors
d. GABA receptors

10: The major difference between typical and atypical antipsychotics is that
a. The latter cause minimal or no increase in prolactin
b. The former cause tardive dyskinesia
c. The former are available as parenteral preparations
d. The latter cause substantial sedation

11: Antipsychotic drug induced parkinsonism is treated by
a. Anticholinergics
b. Levodopa
c. Selegilline
d. Amantadine

12: Oculogyric crisis is known to be produced by all of the following drugs except
a. Trifluoperazine
b. Atropine
c. Perchlorperazine
d. Perphenazine

13: Inverse agonist of benzodiazepine receptor is
a. Phenobarbitone
b. Flumazenil
c. Beta-carboline
d. Gabapentin

14: All of the following are hallucinogens except
a. LSD
b. Phencyclidine
c. Mescaline
d. Methylphenidate

15: All of the following are topically used sulphonamides except
a. Sulphacetamide
b. Sulphadiazine
c. Silver sulphadiazine
d. Mafenide

16: One of the following is not pencillinase susceptible
a. Amoxicillin
b. Pencillin G
c. Piperacillin
d. Cloxacillin

17: The group of antibiotics which possess additional anti-inflammatory and immunomodulatory
      activities is
a. Tetracyclines
b. Polypeptide antibiotics
c. Fluoroquinolones
d. Macrolides

18: Which one of the following is best associated with Lumefantrine?
a. Antimycobacterial
b. Antifungal
c. Antimalarial
d. Antiamoebic

19: Which one of the following is used in therapy of Toxoplasmosis?
a. Artensunate
b. Thiacetazone
c. Ciprofloxacin
d. Pyrimethamine

20: Nevirapine is a
a. Protease inhibitor
b. Nucleoside reverse transcriptase inhibitor
d. Fusion inhibitor

21: Which one of the following drugs is "Topoisomerase I" inhibitor?
a. Doxorubicin
b. Irinotecan
c. Etoposide
d. Vincristine

22: Etanercept acts by one of the following mechanisms
a. By blocking Tumor necrosis factor
b. By blocking bradykinin synthesis
c. By inhibiting COX-2
d. By blocking lipoxygenase


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