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Tuesday, November 15, 2011

Chewing gums are mobile drug delivery systems. It is a potentially useful means of administering
drugs either locally or systemically via, the oral cavity. The medicated chewing gum has through the
years gained increasing acceptance as a drug delivery system. Several ingredients are now
incorporated in medicated chewing gum, e.g. Fluoride for prophylaxis of dental caries, chlorhexidine as
local disinfectant, nicotine for smoking cessation, aspirin as an analgesic, and caffeine as a stay alert
preparation. MCGs are solid, single dose preparations with a base consisting mainly of gums that are
intended to be chewed but not swallowed. They contain one or more active substances which are
released by chewing and are intended to be used for local treatment of mouth diseases or systemic
delivery after absorption through the buccal mucosa.



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