The aim of the current investigation was to formulate floating sustained-release matrices of metoprolol succinate using
Gelucire 43/01 and Gelucire 44/14 by a melt-solidification technique. The in vitro and in vivo characteristics of the
prepared matrices were evaluated. The in vitro drug release studies performed in 0.1 N HCl revealed a proportional
increase in drug release pattern with increased concentration of Gelucire 44/14.
Drug release data were analyzed by various mathematical models, and the mean dissolution time, Dissolution
Efficiency, and similarity factor (f2) were determined in optimizing formulations. Differential scanning calorimetry and
Fourier transform infrared spectroscopy showed no chemical interaction between drug and carriers studied. The in vitro
floating characteristics of Gelucire matrices were greater than 12 h with good in vivo gastric retention. The results indicate
that Gelucire 43/01 is an appropriate carrier for the development of sustained-release floating drug delivery systems and
Gelucire 44/14, a highly hydrophilic and lipophilic balance (HLB) excipient, acts as release enhancer in the formulations
studied.
Journal:
2010dissolutiontechAugust 2010 Volume 17 Issue 3
Copyright:
2010dissolutiontech
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