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Wednesday, July 28, 2010

Pharmaceutics: The Science of Dosage Form Design

A comprehensive textbook covering the design of dosage forms and all aspects of drug delivery systems. 'Pharmaceutics' in its broadest sense is the 'art of the apothecary' or, in simple terms, pharmaceutical preparations. It remains a diverse subject in the pharmacy curriculum, encompassing design of drugs, their manufacture, and the elimination of micro-organisms from the products. This books encompasses all those areas and pays particular attention to the design of dosage forms and their manufacture.

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Smith and Williams' Introduction to the Principles of Drug Design and Action, Fourth Edition


As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states. Smith and Williams' Introduction to the Principles of Drug Design and Action, 4th Edition provides a thorough introduction to the principles of rational drug design, including both novel and established approaches. The fourth edition of this popular textbook adopts a 'from the bench to the marketplace' approach, using real examples where possible. In addition to a comprehensive update of the previous edition, new advances in molecular techniques, biotechnological applications and computer-aided design have been added.

Pharmaceutical Experimental Design And Interpretation


This complete revision of Understanding Experimental Design and Interpretation in Pharmaceutics provides a comprehensive and up-to-date guide for anyone involved in planning pharmaceutical experiments and analysing the results.After a brief discussion of the underlying statistical techniques, the major methods of experimental design and evaluation, such as multivariate analysis, principal components analysis and sequential analysis, are examined. A comprehensive review of factorial design, covering classical, partial and block designs, leads to a description of methods of optimization, including model-independent and model-dependent methods such as response surface methodology and multicriteria decision making. A separate chapter applies these methods to mixture designs which are particularly relevant to pharmaceutical formulations. Each chapter draws on real examples from the pharmaceutical industry making the book a practical aid for all pharmaceutical researchers.

Cancer Drug Design and Discovery


The ultimate source of information on the design of new anticancer agents, emphasising small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumours. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry, and clinicians taking oncology options. 

* Covers both currently available drugs as well as those under development
* Provides a clinical perspective on trials of new anticancer agents
* Presents drug discovery examples through the use of case histories

Modified-Release Drug Delivery Technology

Describing formulation challenges and their solutions in the design, development, and commercialization of modified-release drugs delivery systems, this book contains eighty papers that review recent developments in design and manufacturing techniques. It includes detailed descriptions of extended release drug products for the oral, nasal, ophthalmic, pulmonary, vaginal, dermal and transdermal pathways. With the exception of the final section addressing regulatory issues, each section covers a particular route for drug delivery and opens with an overview of the anatomical, physiological, and pharmaceutical basics of each route before moving on to cover specific technologies.

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Peptide-Based Drug Design: Methods and Protocols

Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular Biology™ series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.


Advanced Drug Design And Development: A Medicinal Chemistry Approach

This volume, entitled Advanced Drug Design and Development: A Medicinal Chemistry Approach, is a collection of lectures by most of the invited speakers in The Department of Pharmaceutical-Medicinal Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki.about the new trends in our science, through the presentations of renowned invited speakers. It is also aimed to create a forum for exchange of ideas in medicinal chemistry, in a different informal environment, bringing internationally recognized medicinal chemists closer to their Greek colleagues.

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Profiles of Drug Substances, Excipients and Related Methodology, Volume 33

Whilst following in the footsteps of previous volumes by presenting comprehensive reviews of drug substances and additional materials, this title also heralds a significant expansion of the scope of the series. Traditional contributions will now also be augmented by publication of critical review chapters that summarize information related to the characterization of drug substances and excipients. This change is required to better meet the needs of the pharmaceutical communtiy and to allow the development of a timely vehicle for publishing review materials on this topic.
The scope of the Profiles series will encompass review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.

* Presents comprehensive reviews covering all aspects of drug development and formulation of drugs
* Now encompassing critical review chapters
* Meets the information needs of the drug development community

Advanced Drug Formulation Design to Optimize Therapeutic Outcomes

This title demonstrates how advanced formulation designs and delivery technologies can be used to improve drug efficacy and treatment outcomes in particular therapeutic categories or disease states. It discusses nanoparticle systems for cancer treatments, and also presents cutting edge immono-regulation agents for transplantation and the local targeting of drugs, especially poorly water soluble drugs to provide enhanced therapeutic outcomes. In addition, this title highlights areas of therapy showing the most promise for improvement in clinical outcomes via advanced formulation design.

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http://rapidshare.com/files/81884254/Adv_Drug_Formu_Design.zip

Analytical Profiles of Drug Substances and Excipients, Volume 29 (APDSE)

Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Analytical Profiles of Drug Substances and Excipients, brings the latest information together in one source.

· Represents a very important contribution to the practice of pharmaceutical analysis
· Presents an excellent overview of physical, chemical, and biomedical properties of some regularly prescribed drugs
· Each volume in the series contains a cumulative index

Download Link:

http://rapidshare.com/files/81869740/Ana_Profiles_DS_Excipients.zip

Free Energy Calculations in Rational Drug Design

Free energy calculations represent the most accurate computational method available for predicting enzyme inhibitor binding affinities. Advances in computer power in the 1990s enabled the practical application of these calculations in rationale drug design. This book represents the first comprehensive review of this growing area of research and covers the basic theory underlying the method, numerous state of the art strategies designed to improve throughput and dozen examples wherein free energy calculations were used to design and evaluate potential drug candidates.

Download Link:

http://rapidshare.com/files/78709528/Free_Energy_Calcu_Drug_Design.zip

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