Drug-Drug Interactions, Second Edition

Helping researchers predict drug interactions in a more accurate and effective manner, this comprehensive volume covers every critical aspect of metabolism-based drug-drug interactions, including preclinical, clinical, toxicological, regulatory, and marketing perspectives by renowned thought leaders in their respective fields. Thoroughly updated, the Second Edition reflects key developments in the field, including an improved understanding of the relationship between transporters and enzymes in drug metabolism and drug interactions. Formatted to benefit the reader, this source provides helpful case examples, representative enzyme systems, and computer-aided modeling, as well as 200 valuable tables, equations, drawings, and photographs to clarify key concepts.

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Principles of Organic Medicinal Chemistry

The book Principles of Organic Medicinal Chemistry describes the principles and concepts of chemistry, synthetic schemes, structure activity relationships, mechanism of action and clinical uses of carbon compounds in the light of modern trends. The book covers the syllabi of B.Pharmacy and M.Pharmacy courses of all Indian Universities.

This book comprises of 22 chapters. Chapter 1 gives an introduction to medicinal chemistry, Chapter 2 explain about the basics on principles of drug action and physicochemical properties of organic medicinal, substances are elaborated in Chapter 3. The concepts of Prodrugs and Drug metabolism are summarized in Chapter 4 and Chapter 5 respectively. Chapter 6 to Chapter 22 explains chemistry, properties, mechanism of action, structure activity relationships, chemistry of newer drugs and clinical uses of various therapeutic agents. At the end of book, a set of more than 200 essays and short questions and 225 objective questions with answers are strategically designed.

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Vitamin B: New Research

The B vitamins are eight water-soluble vitamins that play important roles in cell metabolism. Historically, the B vitamins were once thought to be a single vitamin, referred to as Vitamin B (much like how people refer to Vitamin C or Vitamin D). Later research showed that they are chemically distinct vitamins that often coexist in the same foods. Supplements containing all eight B vitamins are generally referred to as a vitamin B complex. Individual B vitamin supplements are referred to by the specific name of each vitamin (eg B1, B2, B3).The B vitamins often work together to deliver a number of health benefits to the body. B vitamins have been shown to: support and increase the rate of metabolism; maintain healthy skin and muscle tone; enhance immune and nervous system function; promote cell growth and division - including that of the red blood cells that help prevent anemia. Together, they also help combat the symptoms and causes of stress, depression, and cardiovascular disease. All B vitamins are water soluble, and are dispersed throughout the body. They must be replenished daily with any excess excreted in the urine. Vitamin B deficiency can lead to an enormous group of health problems. This book presents new and important research in the field.

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Bioanalytical Separations, Volume 4

Bioanalytical Separations is volume 4 of the multi-volume series, Handbook of Analytical Separations, providing reviews of analytical separation methods and techniques used for the determination of analytes across a whole range of applications. The theme for this volume is bioanalysis, in this case specifically meaning the analysis of drugs and their metabolites in biological fluids.

- Discusses new developments in instrumentation and methods of analyzing drugs and their metabolites in biological fluids

- Provides guidance to the different methods, their relative value to the user, and the advantages and pitfalls of their use

- Future trends are identified, in terms of the potential impact of new technologies.

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Handbook of Drug Metabolism, Second Edition

This timely, expanded new edition is the definitive handbook for experienced drug metabolism and pharmaceutical scientists and those new to the field.

Written by internationally renowned authors, it provides integrated, comprehensive coverage of fundamental aspects of drug metabolism and the practical applications that help guide researchers through key challenges in modern drug discovery and development.

The Second Edition covers the many recent scientific and technical advances in the field, and is organized in four sections – ideal for use in undergraduate and graduate programs in Drug Metabolism and Clinical Pharmacology.

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Pharmacokinetics: Regulatory, Industrial, Academic Perspectives

Offering a unique, multidisciplinary approach, this state-of-the-art Second Edition details the rapidly changing role that clinical and non-clinical pharmacokinetics and drug metabolism play in the discovery and development of drug therapies -- emphasizing often overlooked regulatory, scientific, and economic issues.

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Handbook of Drug Metabolism

Bringing together nearly forty collaborators from academic and industrial laboratories, this reference furnishes an overview of the subject from a historical, kinetic, and chemical context. A source of expertise for a rapidly changing and expanding field, the book provides a framework for drug metabolism in drug discovery and development. Containing tables, drawings, photographs, and equations, it highlights the importance of pharmacokinetics and cytochrome P450, explains clearance, volume of distribution, sequential metabolism, and nonlinear kinetics, summarizes concepts of Phase 1 and 2 metabolites, evaluates tertiary amine metabolism and reactive metabolite chemistry, and more.

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A Handbook of Bioanalysis and Drug Metabolism

Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting until now.

A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drugdrug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills.

This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.

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http://rapidshare.com/files/91668608/Hb_bioana_drug_meta.zip